Citation

Jones AR, Bush HM, Frazier SK. Heart Lung 2017; 46(2): 114-119.

Affiliation

University of Kentucky College of Nursing, 751 Rose St, Lexington, KY 40536-0232, United States.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.hrtlng.2016.12.002

PMID

28088436

Abstract

BACKGROUND: Blood component (packed red blood cells [PRBC], fresh frozen plasma [FFP], platelets [PLT]) ratios transfused in a 1:1:1 fashion are associated with survival after trauma; the relationship among blood component ratios and inflammatory complications after trauma is not fully understood.

OBJECTIVES: To evaluate the relationship among blood component ratios (1:1 vs other for PRBC:FFP and PRBC:PLT) and inflammatory complications (primary outcome) in patients with major trauma.

METHODS: Secondary analysis of a multi-institution database (N = 1538). Survival methods were used to determine the relationship among blood component ratios and inflammatory complications.

RESULTS: Patients were primarily male (68%), Caucasians (89%), aged 39 ± 14 years, involved in a motor vehicle collision (53%). Eighty-six percent of patients developed an inflammatory complication; 76% developed organ failure, 27% ventilator-associated pneumonia, and 24% acute respiratory distress syndrome. Injury severity, sex, and total PRBC transfusion volume, not blood component ratio, predicted inflammatory complications.

CONCLUSIONS: Increased understanding of factors associated with inflammation after trauma and PRBC transfusion is needed.

Copyright © 2016 Elsevier Inc. All rights reserved.

Language: en

Keywords

Blood transfusion; Erythrocyte transfusion; Hemorrhage; Inflammation; Trauma