Citation

Taylor MK, Beckerley SE, Henniger NE, Hernández LM, Larson GE, Granger DA. Psychiatry Res. 2017; 249: 304-306.

Affiliation

Institute for Interdisciplinary Salivary Bioscience Research, University of California, USA, Irvine, CA 92697, USA; Johns Hopkins University School of Nursing, and Johns Hopkins University Bloomberg School of Public Health, 3400 North Charles Street, Baltimore, MD 21218, USA.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.psychres.2017.01.002

PMID

28142104

Abstract

We evaluated associations of five candidate polymorphisms (Bcl1 [rs41423247], -2C/G [rs2070951], COMT [rs737865], Val66Met [rs6265], and 5HTTLPR [biallelic and triallelic [5HTTLPR/rs25531]) with probable MDD and suicidal ideation (SI), the effects of physical activity on these endpoints, and whether physical activity attenuates genetic risk in military members (N=736). C carriers who were also less physically active were 3.3 times as likely to meet criteria for probable MDD and 9.6 times as likely to endorse SI as compared to physically active GG carriers. An adequate dose of physical activity diminishes risk of MDD and SI imposed by a genetic predisposition.

Published by Elsevier B.V.

Language: en

Keywords

Exercise; Polymorphism; Suicide