Citation

Malherbe PJ, Karayiorgou M, Ehlers R, Roos JL. Psychiatry Res. 2017; 251: 34-35.

Affiliation

Department of Psychiatry, University of Pretoria, South Africa.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.psychres.2017.02.008

PMID

28189075

Abstract

We link schizophrenia in families from the genetically isolated South African Afrikaner population to chromosome 13q (n =51), 1p (n =23) and combined 13q & 1p (n =18). Patients with linkages to chromosome 13q were 4.16 times more likely to meet diagnostic criteria for schizoaffective disorder compared to patients with linkage to 1p. A third of patients with linkage to both 13q &1p met diagnostic criteria for SAD. There was a significant positive relationship between suicidality and a diagnosis of schizoaffective disorder. Identifying linkage to chromosome 13q may be informative in identifying suicide risk early and prevent morbidity and mortality in schizophrenia patients.

Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Language: en

Keywords

Linkage to chromosome 13q; Schizoaffective disorder; Suicide