Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism

Agrawal, Arpana; Tillman, Rebecca; Grucza, Richard A.; Nelson, Elliot C.; McCutcheon, Vivia V.; Few, Lauren; Conner, Kenneth R.; Lynskey, Michael T.; Dick, Danielle M.; Edenberg, Howard J.; Hesselbrock, Victor M.; Kramer, John R.; Kuperman, Samuel; Nurnberger, John I.; Schuckit, Marc A.; Porjesz, Bernice; Bucholz, Kathleen K.

doi:10.1016/j.jad.2016.12.060

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Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism
Citation	Agrawal A, Tillman R, Grucza RA, Nelson EC, McCutcheon VV, Few L, Conner KR, Lynskey MT, Dick DM, Edenberg HJ, Hesselbrock VM, Kramer JR, Kuperman S, Nurnberger JI, Schuckit MA, Porjesz B, Bucholz KK. J. Affect. Disord. 2017; 213: 96-104.
Affiliation	Washington University School of Medicine, Dept. of Psychiatry, St. Louis, MO, USA.
Copyright	(Copyright © 2017, Elsevier Publishing)
DOI	10.1016/j.jad.2016.12.060
PMID	28213124
Abstract	BACKGROUND: Substance use and misuse and suicidal thoughts and behaviors tend to co-occur. The purpose of this study was to examine whether (a) suicidal ideation and attempt are related to onset of alcohol, nicotine and cannabis use and dependence; (b) early use of alcohol, nicotine and cannabis is associated with onset of suicidal ideation and attempt; and (c) whether these associations persist while controlling for covariates, such as family history of alcohol problems, major depression and other internalizing and externalizing disorders. METHODS: The prospective cohort of the Collaborative Study of the Genetics of Alcoholism (COGA; N=3277) was used. Cross-sectional and discrete time logistic regression (i.e. survival) analyses examined associations between suicidal ideation and attempt and onset of alcohol, nicotine and cannabis use and dependence. Survival models also examined whether individual early substance use was related to onset of ideation and attempt. RESULTS: Ideation was related to 0.71-0.77 odds of onset of subsequent alcohol, nicotine and cannabis use. Attempt was associated with 1.44-1.61 odds of later alcohol, nicotine and cannabis dependence, even after accounting for covariates. Evidence for early substance use being related to subsequent onset of ideation or attempt was limited. Several sex and race differences emerged. LIMITATIONS: The sample was ascertained for family history of alcoholism; not all participants had been followed up allowing for censored observations; reporting bias. CONCLUSION: Suicide attempts are associated with increased likelihood of onset of substance dependence. Copyright © 2017 Elsevier B.V. All rights reserved. Language: en
Keywords	Alcohol; Attempt; COGA; Cannabis; Ideation; Nicotine; Suicide