Citation

Mary Fonseka T, McKinley GP, Kennedy SH. Psychiatry Res. 2017; 251: 253-254.

Affiliation

University of Toronto, Arthur Sommer Rotenberg Chair in Suicide & Depression Studies, St. Michael's Hospital, Canadian Biomarker Integration Network for Depression, University Health Network, 399 Bathurst St., Toronto, Ontario Canada M5T 2S8. Electronic address: Sidney.kennedy@uhn.ca.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.psychres.2017.01.003

PMID

28219024

Abstract

Prior to the mid-1980s, suicide in Indigenous population in Northwestern Ontario, Canada, was rare, occurring at rates of 1-2 per year among over 20 communities. By the early 1990s, the completed suicide rates in the same communities were among the highest in the world. Prior to the outbreak of the suicide epidemic, sniffing of gasoline containing tetraethyl was common in many communities. Existing literature confirms that tetraethyl lead poisoning is associated with alterations to the amyloid-β protein precursor and amyloid-β as well as the 5-HT-1B receptor. The presence of this risk factor within the population warrants further inquiry.

Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Language: en