Citation

Liu L, Cheng J, Li H, Su Y, Sun L, Yang L, Qian Q, Wang Y. Psychiatry Res. 2017; 252: 185-187.

Affiliation

Peking University Sixth Hospital/Institute of Mental Health, Beijing, China; National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. Electronic address: wangyf@bjmu.edu.cn.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.psychres.2017.02.055

PMID

28284086

Abstract

Y chromosome plays important role in brain function and may help to explain the sex difference in attention-deficit/hyperactivity disorder (ADHD). A total of 857 boys with ADHD and 574 male controls were genotyped for 14 Y-linked markers. Analyses for both dichotomous phenotype and quantitative traits and the interaction effects with MAOA were performed. The results indicated significant association of four markers (M88, M95, M175, and M119) with inhibition function and aggression in boys with ADHD. Positive interaction effects with MAOA were also detected. In conclusion, some Y-linked variants may be associated with the impulsivity and aggression in boys with ADHD.

Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Language: en

Keywords

ADHD; Externalizing behavior; Y-linked variants