Citation

Lucke-Wold BP, Turner RC, Logsdon AF, Rosen CL, Qaiser R. J. Surg. Emerg. Med. 2017; 1(1): e3.

Affiliation

Department of Neurosurgery, West Virginia University, Morgantown, WV, USA.

Copyright

(Copyright © 2017, iMed Publishing)

DOI

unavailable

PMID

28386605

PMCID

PMC5380369

Abstract

Neurotrauma from blast exposure is one of the single most characteristic injuries of modern warfare. Understanding blast traumatic brain injury is critical for developing new treatment options for warfighters and civilians exposed to improvised explosive devices. Unfortunately, the pre-clinical models that are widely utilized to investigate blast exposure are based on archaic lung based parameters developed in the early 20th century. Improvised explosive devices produce a different type of injury paradigm than the typical mortar explosion. Protective equipment for the chest cavity has also improved over the past 100 years. In order to improve treatments, it is imperative to develop models that are based more on skull-based parameters. In this mini-review, we discuss the important anatomical and biochemical features necessary to develop a skull-based model.

Language: en

Keywords

Anatomical correlates; Biomarkers; Blast traumatic brain injury; Clinically relevant models; Skull-based scaling