Citation

Colin-Benoit E, Friolet R, Rusca M, Teta D, Gobin N. Nephrol. Ther. 2017; 13(3): 183-187.

Vernacular Title

Intoxication sévère à la caféine traitée par hémodialyse et hémodiafiltration.

Affiliation

Service de médecine interne, département de médecine et de gériatrie, centre hospitalier du Valais-Romand, 80, avenue du Grand-Champsec, 1950 Sion, Suisse.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.nephro.2016.10.005

PMID

28455110

Abstract

A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet. Mechanisms of action are dose-dependent. When caffeine overdosing occurs, neurologic, cardiovascular and renal systems are mainly affected. Severe intoxication can be fatal. No antidote is available and treatment is purely symptomatic. Hemoperfusion has previously been carried out in the 1990's to treat patients with caffeine intoxication. Since 2009, hemodialysis and hemofiltration have proposed as well. Our patient was successfully treated with a combination of hemodiafiltration, intermittent and then continuous.

Copyright © 2017 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.

Language: fr

Keywords

Caffeine; Caféine; Continuous hemodiafiltration; Hemodialysis; Hémodiafiltration continue; Hémodialyse; Intoxication