Citation

Halliday DWR, Hundza SR, Garcia-Barrera MA, Klimstra M, Commandeur D, Lukyn TV, Stawski RS, MacDonald SWS. J. Clin. Exp. Neuropsychol. 2018; 40(2): 151-160.

Affiliation

c Institute of Aging and Lifelong Health , University of Victoria , Victoria , BC , Canada.

Copyright

(Copyright © 2018, Informa - Taylor and Francis Group)

DOI

10.1080/13803395.2017.1325453

PMID

28565933

Abstract

OBJECTIVE: Falls represent a major concern for older adults and may serve as clinically salient index events for those presenting in the prodromal stages of mild cognitive impairment. Declines in executive function performance and in gait consistency have shown promise in predicting fall risk; however, associated neurophysiological underpinnings have received less attention. In this study, we used a multimodal approach to assess fall risk in a group of older adults with and without a previous fall history.

METHOD: Processing speed, inductive reasoning, verbal fluency, crystallized ability, episodic memory, and executive functioning were assessed using standardized neuropsychological tests. Cognitive interference was assessed using the Multi-Source Interference Task. Spatiotemporal gait parameters were assessed with and without cognitive load using a 6.4-m instrumented walkway. Hemodynamic responses were measured using functional near-infrared spectroscopy.

RESULTS: Whereas no group differences were observed in cognitive behavioral performance, during a cognitive interference task fallers displayed more oxygenated hemoglobin across the prefrontal cortex than nonfallers, suggesting that engaging in the cognitive task was more effortful for them overall, therefore eliciting greater cortical activation. Between-group differences in spatial as well as temporal gait parameters were also observed.

CONCLUSIONS: These results are in keeping with assertions that diminished executive control is related to fall risk. Notably, the group differences observed in prefrontal cortical activation and in gait parameters may ultimately precede those observed in cognitive behavioral performance, with implications for measurement sensitivity and early identification.

Language: en

Keywords

Aging; fall risk; functional near-infrared spectroscopy (fNIRS); multimodal assessment; variability