Citation

Gupta A, Tripathi A, Sharma P. Sleep Breath. 2017; 21(3): 781-789.

Affiliation

Department of Orthodontics, Dental College, Azamgarh, India.

Copyright

(Copyright © 2017, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11325-017-1534-1

PMID

28695399

Abstract

BACKGROUND: Obstructive sleep apnea (OSA) manifests as a reduction or complete cessation of airflow despite an ongoing inspiratory effort, leading to hypoxemia and hypercapnia. The inability to maintain normal breathing reduces the oxygen saturation in blood leading to a cycle of various systemic implications. Hence, a prospective single arm study was planned to evaluate the long-term (2 years) effect of oral appliance on cardiovascular fitness and psychomotor performance in patients with mild to moderate obstructive sleep apnea.

METHODS: Thirty dentulous OSA patients (25 males; 5 females; age 41 ± 4 years; BMI 22 ± 5; AHI 5-30) were included in the study. All the patients were assessed for systolic blood pressure (SBP), diastolic blood pressure (DBP), apnea/hypopnea index (AHI), lipid peroxidation, and psychomotor vigilance test at baseline, 6 months, 1 year, and 2 years after wearing mandibular advancement splint (MAS).

RESULTS: A significant reduction in AHI, blood pressure, and lipid peroxidation was observed following MAS use. Psychomotor vigilance test showed marked improvement in response time with almost 0 count of lapses after 2 years of MAS use.

CONCLUSIONS: The present study suggested that MAS can be helpful in improving cardiovascular fitness and cognitive response in patients with mild to moderate OSA.

Language: en

Keywords

Apnea/hypopnea index (AHI); Mandibular advancement splint; Obstructive sleep apnea; Oxidative stress; Psychomotor vigilance test