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Citation
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Balogun S, Winzenberg T, Wills K, Scott D, Jones G, Aitken D, Callisaya ML. J. Nutr. Health Aging 2017; 21(7): 843-848. |
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Affiliation
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Dr Michele L. Callisaya, Menzies Institute for Medical Research, Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia; Email: Michele.Callisaya@utas.edu.au, Phone: (03) 6226 4785, Fax: (03) 6226 7704. |
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Abstract
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OBJECTIVES: Purpose: To compare the performance of low muscle mass and function with falls risk, incident fracture and mortality over 10 years.
METHODS: 1041 participants (50% women; mean age 63±7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry. Four anthropometric: (ALM/height2, ALM/body mass index, ALM/weight×100, a residuals method of ALM on height and total body fat) and four performance-based measures: (handgrip strength, lower-limb muscle strength, upper and lower-limb muscle quality) were examined. Participants in the lowest 20% of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function. Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk, incident fractures and mortality.
RESULTS: Mean falls risk z-score at 10 years was 0.64 (SD 1.12), incident fractures and mortality over 10 years were 16% and 14% respectively. All baseline performance-based measures were significantly associated with higher falls risk score at 10 years. Low handgrip (RR 1.55, 95% CI: 1.09, 2.20) and ALM/body mass index (RR 1.54, 95% CI: 1.14, 2.08) were the only significant predictors of fracture and mortality respectively.
CONCLUSIONS: Low handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures. ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.
Language: en |