Citation

Al-Tarrah K, Moiemen N, Lord JM. Burns Trauma 2017; 5: e29.

Affiliation

Institute of Inflammation and Ageing, Birmingham University Medical School, B15 2TT, Birmingham, UK.

Copyright

(Copyright © 2017, Institute of Burn Research, Southwest Hospital, Third Military Medical University, China, Publisher Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s41038-017-0093-9

PMID

28920065

PMCID

PMC5597997

Abstract

Trauma and related sequelae result in disturbance of homeostatic mechanisms frequently leading to cellular dysfunction and ultimately organ and system failure. Regardless of the type and severity of injury, gender dimorphism in outcomes following trauma have been reported, with females having lower mortality than males, suggesting that sex steroid hormones (SSH) play an important role in the response of body systems to trauma. In addition, several clinical and experimental studies have demonstrated the effects of SSH on the clinical course and outcomes following injury. Animal studies have reported the ability of SSH to modulate immune, inflammatory, metabolic and organ responses following traumatic injury. This indicates that homeostatic mechanisms, via direct and indirect pathways, can be maintained by SSH at local and systemic levels and hence result in more favourable prognosis. Here, we discuss the role and mechanisms by which SSH modulates the response of the body to injury by maintaining various processes and organ functions. Such properties of sex hormones represent potential novel therapeutic strategies and further our understanding of current therapies used following injury such as oxandrolone in burn-injured patients.

Language: en

Keywords

Burn; Estradiol; Oestrogen; Sex hormones; Sex steroid hormones; Testosterone; Trauma