Citation

Wilkinson DA, Pandey AS, Thompson BG, Keep RF, Hua Y, Xi G. Neuropharmacology 2018; 134(Pt B): 240-248.

Affiliation

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: guohuaxi@umich.edu.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.neuropharm.2017.09.033

PMID

28947377

Abstract

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials.

Copyright © 2017. Published by Elsevier Ltd.

Language: en

Keywords

Brain edema; Hematoma; Hypertension; Intracerebral hemorrhage; Iron; Thrombin