Citation

Chen HM, Chen VC, Wang TN, Lu ML, Huang YC, Dewey ME, Lee JK, Tsai CP. Gen. Hosp. Psychiatry 2017; 50: 45-50.

Affiliation

Department of Neurology, Taipei Veterans General Hospital, Taiwan; Department of Biotechnology, Asia University, Taiwan. Electronic address: cptsai@vghtpe.gov.tw.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.genhosppsych.2017.09.008

PMID

29017085

Abstract

OBJECTIVE: Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study.

METHODS: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010. These cases were compared with 6568 gender-, age-, residence-, and insurance premium-matched controls. Both suicide and non-suicide study patients were drawn from a group with previous psychiatric diagnoses. The risk of suicide among patients with diseases of the pancreas was analyzed using a conditional logistic regression model that controlled for alcohol-related disorder, drug dependence, schizophrenia, depressive disorder, bipolar disorder, anxiety disorder, Charlson comorbidity score, and outpatient visits.

RESULTS: Disease of the pancreas was an independent risk factor for psychiatric patients who had completed suicide when adjusted for clinical and other comorbid factors. Among these covariates, alcohol-related disorders partially mediate the suicide risk among patients with disease of the pancreas, and mental disorders may not mediate this suicide risk.

CONCLUSIONS: Diseases of the pancreas were associated with increased risk of completed suicide after controlling for potential confounding factors.

Copyright © 2017 Elsevier Inc. All rights reserved.

Language: en

Keywords

Diseases of the pancreas; Mental disorders; Pancreatitis; Suicide