Citation

Reczyńska K, Tharkar P, Kim SY, Wang Y, Pamuła E, Chan HK, Chrzanowski W. Adv. Drug Deliv. Rev. 2018; 123: 107-134.

Affiliation

The University of Sydney, Faculty of Pharmacy, NSW 2006, Sydney, Australia; Australian Institute for Nanoscale Science and Technology, The University of Sydney, NSW 2006, Sydney, Australia. Electronic address: wchrzanowski@sydney.edu.au.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.addr.2017.10.005

PMID

29108862

Abstract

Smoke inhalation injury leads to various acute and chronic lung diseases and thus is the dominant cause of fire-related fatalities. In a search for an effective treatment and validation of therapies different classes of animal models have been developed, which include both small and large animals. These models have advanced our understanding of the mechanism of smoke inhalation injury, enabling a better understanding of pathogenesis and pathophysiology and development of new therapies. However, none of the animal models fully mirrors human lungs and their pathologies. All animal models have their limitations in replicating complex clinical conditions associated with smoke inhalation injury in humans. Therefore, for a correct interpretation of the results and to avoid bias, a precise understanding of similarities and differences of lungs between different animal species and humans is critical. We have reviewed and presented comprehensive comparison of different animal models and their clinical relevance. We presented an overview of methods utilized to induce smoke inhalation injuries, airway micro-/ macrostructure, advantages and disadvantages of the most commonly used small and large animal models.

Copyright © 2017 Elsevier B.V. All rights reserved.

Language: en

Keywords

large animals; lung injury models; small animals; smoke inhalation