Citation

Bell MJ, Adelson PD, Wisniewski SR. Childs Nerv. Syst. 2017; 33(10): 1663-1667.

Affiliation

Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.

Copyright

(Copyright © 2017, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00381-017-3530-y

PMID

29149394

Abstract

Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

Language: en

Keywords

Children; Comparative effectiveness research; Evidenced-based guidelines; Pediatric neurocritical care; Pediatric neurotrauma; Severe traumatic brain injury