Citation

Olliac B, Ouss L, Charrier A. J. Physiol. (Paris) 2016; 110(4 Pt B): 461-466.

Affiliation

Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent (PHUPEA), Université de Rennes 1, Centre Hospitalier Guillaume-Régnier, 154 Rue de Châtillon, 35000 Rennes, France. Electronic address: a.charrier@ch-guillaumeregnier.fr.

Copyright

(Copyright © 2016, Elsevier Publishing)

DOI

10.1016/j.jphysparis.2017.11.001

PMID

29154930

Abstract

Suicide remains one of the leading causes of death among young people, and suicidal ideation and behavior are relatively common in healthy and clinical populations. Suicide risk in childhood and adolescence is often approached from the perspective of nosographic categories to which predictive variables for suicidal acts are often linked. The cascading effects resulting from altered clock genes in a pediatric population could participate in biological rhythm abnormalities and the emergence of suicide attempts through impaired regulation of circadian rhythms and emotional states with neurodevelopmental effects. Also, early trauma and stressful life events can alter the expression of clock genes and contribute to the emergence of suicide attempts. Alteration of clock genes might lead to desynchronized and abnormal circadian rhythms impairing in turn the synchronization between external and internal rhythms and therefore the adaptation of the individual to his/her internal and external environment with the development of psychiatric disorders associated with increased risk for suicide attempts.

Copyright © 2017. Published by Elsevier Ltd.

Language: en

Keywords

Adolescence; Clock genes; Life events; Rhythms; Suicidal behavior; Suicide