Citation

Genrikhs EE, Voronkov DN, Kapkaeva MR, Isaev NK, Stelmashook EV. Bull. Exp. Biol. Med. 2017; 164(2): 211-213.

Affiliation

Research Center of Neurology, M. V. Lomonosov Moscow State University, Moscow, Russia. estelmash@mail.ru.

Copyright

(Copyright © 2017, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s10517-017-3960-2

PMID

29177900

Abstract

A cascade of pathological changes in the intact hemisphere developed in rats 6 months after focal unilateral traumatic brain injury: neuronal degeneration, hyperexpression of α-synuclein, APP (β-amyloid peptide precursor) protein, and glutamine synthetase in cells other than astrocytes. The development of these changes in the contralateral hemisphere indicated the emergence of extensive delayed neurodegenerative processes in the brain after traumatic brain injury, which were characteristic of diseases associated with pathological aging.

Language: en

Keywords

APP protein; traumatic brain injury; α-synuclein