Citation

Malhi GS, Morris G, Hamilton A, Outhred T, Mannie Z. Bipolar Disord. 2017; 19(8): 627-636.

Affiliation

CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW,, Australia.

Copyright

(Copyright © 2017, John Wiley and Sons)

DOI

10.1111/bdi.12576

PMID

29268003

Abstract

BACKGROUND: The notion of early intervention is understandably appealing for conditions such as bipolar disorder (BD), a chronic life-long illness that increases risk of suicide and diminishes quality of life. It is purported that intervening early in the course of the illness with suitable interventions could substantially alter the trajectory of BD and improve outcomes. However, while there are obvious benefits to the prompt commencement of treatment, it is important to consider the gaps in our understanding regarding the aetiopathogenesis of bipolar disorder-upon which the paradigm of early intervention is predicated.

METHODS: A literature search was undertaken using recognized search engines: PubMed, PsycINFO Medline, and Scopus, along with auxiliary manual searches.

RESULTS: This review first examines how the unpredictable nature of BD creates substantial difficulties when determining an optimal therapeutic target for early intervention. Second, the challenges with identifying appropriate populations and apposite times for early intervention strategies is discussed. Finally, the risks associated with intervening early are examined, highlighting the potential harmful effects of initiating medication.

CONCLUSION: Early intervention for BD is a potentially useful strategy that warrants investigation, but until the emergence and trajectory of the illness are definitive, and a clear view of key targets is achieved, a more conservative approach to treating nascent BD and its antecedent symptoms is needed.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Language: en

Keywords

bipolar disorder; bipolar prodrome; clinical; diagnosis; early intervention; interventions; mood disorders; prevention; staging; treatment