Citation

de Boer SF. Curr. Opin. Psychol. 2018; 19: 81-87.

Affiliation

Department of Behavioral Neuroscience, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, P.O. Box 11103, 9700 CC Groningen, The Netherlands. Electronic address: s.f.de.boer@rug.nl.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.copsyc.2017.04.006

PMID

29279228

Abstract

Escalated interpersonal aggression and violence are common symptoms of multiple psychiatric disorders and represent a significant global health issue. Current therapeutic strategies are limited due to a lack of understanding about the neural and molecular mechanisms underlying the 'vicious' shift of normal adaptive aggression into violence, and the environmental triggers that cause it. Development of novel animal models that validly capture the salient features of human violent actions combined with newly emerging technologies for mapping, measuring, and manipulating neuronal activity in the brain significantly advance our understanding of the etiology, neuromolecular mechanisms, and potential therapeutic interventions of excessive aggressive behaviors in humans.

Copyright © 2017 Elsevier Ltd. All rights reserved.

Language: en