Citation

Greene RD, Wang S. Psychiatr. Clin. North Am. 2018; 41(1): 111-126.

Affiliation

Richard L. Roudebush VAMC, 1481 W. 10th Street, Indianapolis, IN 46202, USA; Department of Pyschiatry, Indiana University School of Medicine, Goodman Campbell Neuroscience Center, 355 W. 16th Street, Indianapolis, IN 46202, USA; Center of Health Innovation and Implementation Science, Center for Translational Science and Innovation, Indianapolis, IN, USA; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN, USA.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.psc.2017.10.009

PMID

29412840

Abstract

This article covers current research on the relationship between depression and cognitive impairment in older adults. First, it approaches the clinical assessment of late-life depression and comorbid cognitive impairment. Cognitive risk factors for suicide are discussed. Research is then provided on neuropsychological changes associated with depression, discussing subjective cognitive impairment, mild cognitive impairment, and dementia profiles. Additionally, literature regarding neuroimaging and biomarker findings in depressed older adults is presented. Finally, therapeutic models for treatment of late-life depression are also discussed, including psychotherapy models, holistic treatments, pharmacologic approaches, and brain-stimulation therapies.

Published by Elsevier Inc.

Language: en

Keywords

Antidepressants; Major depressive disorder; Mild cognitive impairment; Neurocognitive disorder; Neuroimaging; Neuropsychological testing; Psychotherapy; Subjective cognitive impairment