Citation

Yavne Y, Amital D, Watad A, Tiosano S, Amital H. Semin Arthritis Rheum 2018; 48(1): 121-133.

Affiliation

Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5262100, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: Howard.Amital@sheba.health.gov.il.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.semarthrit.2017.12.011

PMID

29428291

Abstract

The role of physical and psychological trauma precipitating fibromyalgia is often encountered by physicians, yet a proper systematical review of this association is lacking. Literature searches identified 51 studies which examined the association of fibromyalgia with a preceding traumatic event of physical or emotional nature. The overall quality of evidence of studies included, as assessed by the GRADE criteria, was low, however the majority of studies described a significant association between prior physically traumatic events and the onset of chronic widespread pain or fibromyalgia. Elevated rates of psychological trauma in fibromyalgia patients were demonstrated across the literature and several studies indicate a mediating effect of post-traumatic stress disorder. Potential biological mechanisms for conversion of traumatic events into a chronic pain syndrome, such as fibromyalgia, are discussed.

Copyright © 2018 Elsevier Inc. All rights reserved.

Language: en

Keywords

fibromyalgia; injury; psychological; trauma; trigger