Citation

Richard-Denis A, Beauséjour M, Thompson C, Nguyen BH, Mac-Thiong JM. J. Neurotrauma 2018; 35(15): 1705-1725.

Affiliation

CHU Sainte-Justine, Orthopedic Surgery , 3175 Cote-Sainte-Catherine , Montreal, Quebec, Canada , H3T 1C5 ; Macthiong@gmail.com.

Copyright

(Copyright © 2018, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2017.5403

PMID

29455634

Abstract

Accurately predicting functional recovery in an asset for all clinicians and decision makers involved in the care of patients with acute traumatic spinal cord injury (TSCI). Unfortunately, there is a lack of information on the relative importance of significant predictors of global functional outcome. There is also a need for identifying functional predictors that can be timely optimized by the medical and rehabilitation teams throughout the hospitalizations phases. The main objective of this work was to systematically review and rate early factors that are consistently and independently associated with global functional outcome in individuals with TSCI. A literature search using MEDLINE, EMBASE and Cochrane databases from January 1st 1970 to April 1st 2017 was performed. Two authors independently reviewed the titles and abstracts yielded by this literature search and subsequently selected studies to be included based on predetermined eligibility criteria. Disagreements were resolved by a consensus-based discussion, and if not, by an external reviewer. Data were extracted by three independent reviewers using a standardized table. The quality of evidence of the individual studies was assessed based on the Oxford Centre for Evidence-Based Medicine modified by Wright et al. (2000) as well as the National Institute of Health (2014). Fifteen articles identifying early clinical predictors of functional outcome using multiple regression analyses were included in this systematic review. Based on the compiled data, this review proposes a rating of early factors associated to global functional outcome according to their importance and their potential to be modified by the medical/rehabilitation team throughout the early phases of hospitalization. It also proposes a new conceptual framework that illustrates the impact of specific categories of factors and their interaction with each other. Ultimately, this review aims to guide clinicians and researchers in improving the continuum of care throughout early phases following SCI.

Language: en

Keywords

LOCOMOTOR FUNCTION; REHABILITATION; TRAUMATIC SPINAL CORD INJURY