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Citation |
Witkiewicz Z, Neffe S, Sliwka E, Quagliano J. Crit. Rev. Anal. Chem. 2018; 48(5): 337-371. |
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Affiliation |
Applied Chemistry Department, Argentine Institute for Scientific and Technical Research for the Defense (CITEDEF) , Buenos Aires , Argentina. |
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Copyright |
(Copyright © 2018, Informa - Taylor and Francis Group) |
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DOI |
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PMID |
29533075 |
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Abstract |
Recent advances in analysis of precursors, simulants and degradation products of chemical warfare agents (CWA) are reviewed. Fast and reliable analysis of precursors, simulants and CWA degradation products is extremely important at a time, when more and more terrorist groups and radical non-state organizations use or plan to use chemical weapons to achieve their own psychological, political and military goals. The review covers the open source literature analysis after the time, when the chemical weapons convention had come into force (1997). The authors stated that during last 15 years increased number of laboratories are focused not only on trace analysis of CWA (mostly nerve and blister agents) in environmental and biological samples, but the growing number of research are devoted to instrumental analysis of precursors and degradation products of these substances. The identification of low-level concentration of CWA degradation products is often more important and difficult than the original CWA, because of lower level of concentration and a very large number of compounds present in environmental and biological samples. Many of them are hydrolysis products and are present in samples in the ionic form. For this reason, two or three instrumental methods are used to perform a reliable analysis of these substances. Language: en |
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Keywords |
Analysis of simulants and precursors of chemical warfare agents; capillary electrophoresis; chemical weapons convention; gas chromatography; liquid chromatography; organization for the prohibition of chemical weapons |