Citation

Liu YW, Li S, Dai SS. J. Neuroinflammation 2018; 15(1): e146.

Affiliation

Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Daping Hospital, Army Medical University, Chongqing, 400042, People's Republic of China. tmmubiodss@aliyun.com.

Copyright

(Copyright © 2018, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s12974-018-1173-x

PMID

29776443

Abstract

Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiation, development, and recovery of TBI. Nonetheless, our understanding about neutrophils in TBI is obsolete, and mounting evidences from recent studies have challenged the conventional views. This review summarizes what is known about the relationships between neutrophils and pathophysiology of TBI. In addition, discussions are made on the complex roles as well as the controversial views of neutrophils in TBI.

Language: en

Keywords

Blood-brain barrier; Edema; Nerve recovery; Neurodegeneration; Neuroinflammation; Neutrophils; Polymorphonuclear cell; Traumatic brain injury