Citation

Xiang P, Shen BH, Yan H, Liu W, Shen M, Wu HJ, Zhuo XY. Fa Yi Xue Za Zhi 2018; 34(3): 248-252.

Affiliation

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Copyright

(Copyright © 2018, Si fa bu Si fa jian ding ke xue ji shu yan jiu suo)

DOI

10.12116/j.issn.1004-5619.2018.03.006

PMID

30051661

Abstract

OBJECTIVES: To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault, in order to solve the problem in actual cases.

METHODS: The milky fluid from an actual case was extracted and analyzed using LC-QE, ¹H-NMR and GC-MS, respectively. The accurate masses and cluster ions isotope patterns of unknown compound were obtained by LC-QE. The molecular formula was confirmed as C₁₆H₁₂C₂N₂O based on the protons number of ¹H-NMR. The isomers diclazepam and 4-chlorodiazepam were separated and detected with GC-MS.

RESULTS: The new designer benzodiazepine as diclazepam in the milky fluid was identified. The results provided direct evidence for the investigation and qualitative analysis of such cases.

CONCLUSIONS: The combined application of various methods, including LC-QE, ¹H-NMR and GC-MS, can be used to detect unknown new psychoactive substances.

Copyright© by the Editorial Department of Journal of Forensic Medicine.

Language: zh

Keywords

LC-QE; benzodiazepine; designer drugs; diclazepam; drug-facilitated sexual assault; forensic toxicology