Citation

Elliott MB, Ward SJ, Abood ME, Tuma RF, Jallo JI. Concussion 2017; 2(4): CNC49.

Affiliation

Department of Neurosurgery, Vickie & Jack Farber Institute for Neuroscience Thomas Jefferson University, PA 19107, USA.

Copyright

(Copyright © 2017, The Drake Foundation, Publisher Future Medicine)

DOI

10.2217/cnc-2017-0010

PMID

30202590

PMCID

PMC6122691

Abstract

Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overview of the epidemiology of postconcussion headache, research models used to study this disorder, as well as the proposed mechanisms. An objective of this review is to enhance the understanding of how the endogenous cannabinoid system is essential for maintaining the balance of the CNS and regulating inflammation after injury, and in turn making the endocannabinoid system a potential modulator of the trigeminal response to concussion. The review describes the role of endocannabinoid modulation of pain and the potential for use of phytocannabinoids to treat pain, migraine and concussion.

Language: en

Keywords

cannabinoid; concussion trigeminal; endocannabinoid; migraine; post-traumatic headache