Citation

Mohammadzadeh Shabestari M, Alizadeh L, Moshiri M, Darchini-Maragheh E, Balali-Mood M. Cardiovasc. Toxicol. 2019; 19(3): 220-228.

Affiliation

School of Medicine, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Mahdi.Balali-Mood@ncl.ac.uk.

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s12012-018-9481-z

PMID

30242562

Abstract

It was aimed to investigate possible late cardiac effects of Sulfur mustard (SM) exposure in Iranian veterans. Thirty-eight veterans with late complications of SM exposure were investigated. Clinical history, physical examinations, 12 leads electrocardiography and transthoracic echocardiography were performed. Computed tomography coronary angiography (CTCA) was performed as clinically indicated for angiographic assessment and patients were stratified according to the CTCA findings. Incomplete right bundle branch block and right axis deviation were detected in 3 (7.9%) and 4 (10.5%) cases, respectively. Mean value of left ventricular ejection fraction was 55.7 ± 2.9%. Different degrees of right ventricular dilation was observed in seven (18.4%) patients. All the patients showed mild to moderate degrees of tricuspid regurgitation. Increased pulmonary artery pressure (PAP) was detected in 16 (42.1%) patients. Out of 18 patients who underwent CTCA, non-obstructive and obstructive coronary artery disease (CAD) were observed in three (16.66%) and eight (44.44%) patients, respectively. CAD was stratified to single vessel (5.5%), two vessels (27.8%) and three vessels disease (11.1%). Mean coronary artery calcium score was 50.91 ± 115.58. SM has cardiovascular toxicity, as a delayed complication of this chemical warfare poisoning.

Language: en

Keywords

CT coronary angiography; Coronary artery disease; Electrocardiography; Poisoning; Sulfur mustard; Transthoracic echocardiography