Citation

Schlomer GL, Cleveland HH, Deutsch AR, Vandenbergh DJ, Feinberg ME, Greenberg MT, Spoth RL, Redmond C. J. Youth Adolesc. 2019; 48(1): 71-85.

Affiliation

Partnerships in Prevention Science Institute, Iowa State University, Ames, IA, USA.

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s10964-018-0929-z

PMID

30244312

Abstract

Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.

Language: en

Keywords

Delinquency; GABRA2; Genetic; GxE; Intervention