Citation

Studlack PE, Keledjian K, Farooq T, Akintola T, Gerzanich V, Simard JM, Keller A. Brain Inj. 2018; 32(13-14): 1866-1878.

Affiliation

a Program in Neuroscience and Department of Anatomy and Neurobiology , University of Maryland School of Medicine , Baltimore , MD , USA.

Copyright

(Copyright © 2018, Informa - Taylor and Francis Group)

DOI

10.1080/02699052.2018.1536282

PMID

30346868

Abstract

Blast-induced traumatic brain injury (blast-TBI) is associated with vestibulomotor dysfunction, persistent post-traumatic headaches and post-traumatic stress disorder, requiring extensive treatments and reducing quality-of-life. Treatment and prevention of these devastating outcomes require an understanding of their underlying pathophysiology through studies that take advantage of animal models. Here, we report that cranium-directed blast-TBI in rats results in signs of pain that last at least 8 weeks after injury. These occur without significantly elevated behavioural markers of anxiety-like conditions and are not associated with glial up-regulation in sensory thalamic nuclei. These injuries also produce transient vestibulomotor abnormalities that resolve within 3 weeks of injury. Thus, blast-TBI in rats recapitulates aspects of the human condition.

Language: en

Keywords

chronic pain; neurotrauma; trauma