Citation

Wei HT, Pan TL, Hsu JW, Huang KL, Bai YM, Ko NY, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Chen MH. J. Affect. Disord. 2018; 245: 335-339.

Affiliation

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: kremer7119@gmail.com.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.jad.2018.11.057

PMID

30419534

Abstract

BACKGROUND: Previous studies have suggested that the unaffected siblings of patients with attention-deficit hyperactivity disorder (ADHD) experience deficits in attention, impulsivity control, and behavior inhibition, which are associated with health-risk behaviors. However, risks to mental and physical health among the unaffected siblings of ADHD probands have rarely been investigated.

METHODS: Using the Taiwan National Health Insurance Research Database, 5128 unaffected siblings of ADHD probands born between 1980 and 2000 were included in our study along with 20,512 age- and sex-matched controls, and they were followed from 1996 or birth until the end of 2011. Mental and physical health risks, including affective disorders, traumatic brain injury (TBI), and sexually transmitted infection were identified during the follow-up period.

RESULTS: Logistic regression analyses with adjustments for demographic data showed that the unaffected siblings were more likely to develop unipolar depression (odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.39-2.22), bipolar disorder (OR: 2.10, 95% CI: 1. 09-4.05), and TBI (OR: 1.24, 95% CI: 1.14-1.36) than were the control group.

DISCUSSION: The unaffected siblings of patients with ADHD were prone to developing unipolar depression, bipolar disorder, and TBI later in life.

Copyright © 2018. Published by Elsevier B.V.

Language: en

Keywords

ADHD; Bipolar disorder; Traumatic brain injury; Unaffected siblings; Unipolar depression