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Citation |
Ning YL, Yang N, Chen X, Tian HK, Zhao ZA, Zhang XZ, Liu D, Li P, Zhao Y, Peng Y, Wang ZG, Chen JF, Zhou YG. Toxicol. Lett. 2019; 301: 90-97. |
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Affiliation |
Molecular Biology Center, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing 400038, China; Collaborative Innovation Center for Brain Science, Army Medical University, Chongqing 400038, China. Electronic address: ygzhou@tmmu.edu.cn. |
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Copyright |
(Copyright © 2019, Elsevier Publishing) |
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DOI |
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PMID |
30423366 |
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Abstract |
Caffeine is a substance that is consumed worldwide, and it may exert neuroprotective effects against various cerebral insults, including neurotrauma, which is the most prevalent injury among military personnel. To investigate the effects of caffeine on high-intensity blast wave-induced severe blast injury in mice, three different paradigms of caffeine were applied to male C57BL/6 mice with severe whole body blast injury (WBBI). The results demonstrated that chronic caffeine treatment alleviated blast-induced traumatic brain injury (bTBI); however, both chronic and acute caffeine treatments exacerbated blast-induced lung injuries and, more importantly, increased both the cumulative and time-segmented mortalities postinjury. Interestingly, withdrawing caffeine intake preinjury resulted in favorable outcomes in mortality and lung injury, similar to the findings in water-treated mice, and had the trend to attenuate brain injury. These findings demonstrated that although drinking coffee or caffeine preparations attenuated blast-induced brain trauma, these beverages may place personnel in the battlefield at high risk of casualties, which will help us re-evaluate the therapeutic strategy of caffeine application, particularly in multiple-organ-trauma settings. Furthermore, these findings provided possible strategies for reducing the risk of casualties with caffeine consumption, which may help to change the coffee-drinking habits of military personnel. Language: en |
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Keywords |
blast-induced traumatic brain injury; caffeine; lung injury; major trauma; mortality; severe blast injury |