Citation

Carvalho CM, Pan PM, Ota VK, Spindola LM, Xavier G, Santoro ML, Mazzotti DR, Pellegrino R, Hakonarson H, Rohde LAP, Miguel EC, Gadelha A, Bressan RA, Belangero SI. Psychiatry Res. 2019; 273: 575-577.

Affiliation

Genetics Division of the Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LiNC), UNIFESP, Brazil; Department of Psychiatry, UNIFESP, Brazil. Electronic address: sinbelangero@gmail.com.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.psychres.2019.01.078

PMID

30716596

Abstract

We evaluated the effects of the interaction between child maltreatment (CM) and single nucleotide polymorphisms (SNPs) on development of mental disorders (MD) and psychopathology. We genotyped 720 individuals from a Brazilian community school-based prospective study, focusing on SNPs in 21 genes known to be associated with mental disorders. CM was assessed via a multi-informant-measure, which was previously validated. To test G × CM, we used linear or logistic models depending on variable evaluated (MD or dimensional psychopathology). After Bonferroni multiple comparison correction, we did not find any statistically significant association of G × CM with either MD or psychopathology.

Copyright © 2019. Published by Elsevier B.V.

Language: en

Keywords

Child maltreatment; G × E-interaction; Psychopathology