Citation

Peurichard D, Ousset M, Paupert J, Aymard B, Lorsignol A, Casteilla L, Degond P. J. Theor. Biol. 2019; 469: 127-136.

Affiliation

Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.jtbi.2019.02.017

PMID

30807758

Abstract

After injury, while regeneration can be observed in hydra, planaria and some vertebrates, regeneration is rare in mammals and particularly in humans. In this paper, we investigate the mechanisms by which biological tissues recover after injury. We explore this question on adipose tissue, using the mathematical framework recently developed in Peurichard et al., J. Theoret. Biol. 429 (2017), pp. 61-81. Our assumption is that simple mechanical cues between the Extra-Cellular Matrix (ECM) and differentiated cells can explain adipose tissue morphogenesis and that regeneration requires after injury the same mechanisms. We validate this hypothesis by means of a two-dimensional Individual Based Model (IBM) of interacting adipocytes and ECM fiber elements. The model successfully generates regeneration or scar formation as functions of few key parameters, and seems to indicate that the fate of injury outcome could be mainly due to ECM rigidity.

Copyright © 2019. Published by Elsevier Ltd.

Language: en

Keywords

Constrained minimization; Fiber insemination; Individual-based model; Regeneration; Tissue remodeling