Citation

Schneider ALC, Selvin E, Liang M, Latour L, Turtzo LC, Koton S, Coresh J, Mosley T, Whitlow CT, Zhou Y, Wong D, Ling G, Gottesman RF. J. Neurotrauma 2019; ePub(ePub): ePub.

Affiliation

Johns Hopkins University School of Medicine, Neurology, Baltimore, Maryland, United States ; rgottesm@jhmi.edu.

Copyright

(Copyright © 2019, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2018.6213

PMID

30963804

Abstract

Our objective was to examine associations of head injury with total and regional brain amyloid deposition. We performed cross-sectional analyses of 329 non-demented participants (81 with prior head injury) in the Atherosclerosis Risk in Communities-Positron Emission Tomography (ARIC-PET) Study who underwent 18-Florbetapir PET imaging in 2012-2014. A history of head injury was defined by self-report or emergency room/hospitalization ICD-9 codes. Generalized linear regression models adjusted for demographic, socioeconomic, and dementia/cardiovascular risk factors were used to estimate prevalence ratios (PRs) (95% confidence intervals [CIs]) for elevated (>1.2) global and regional standard uptake value ratios (SUVRs). Mean age of participants was 76 years, 57% were women, and 43% were black. Head injury was associated with increased prevalence of elevated SUVR >1.2 globally (PR: 1.31, 95% CI: 1.19-1.57), as well as in the orbitofrontal cortex (PR: 1.23, 95% CI: 1.04-1.46), prefrontal cortex (PR: 1.18, 95% CI: 1.00-1.39), superior frontal cortex (PR: 1.24, 95% CI: 1.05-1.48), and posterior cingulate (PR: 1.26, 95% CI: 1.04-1.52). There was also evidence for a dose-response relationship, whereby a history of 1 head injury was associated with elevated SUVR >1.2 in the prefrontal cortex and superior frontal cortex compared to persons with a history of 1 head injury (all p<0.05). In conclusion, head injury was associated with increased amyloid deposition globally and in the frontal cortex and posterior cingulate, with suggestion of a dose-response association of head injuries with beta-amyloid deposition. Further work is needed to determine if increased amyloid deposition contributes to dementia in this population.

Language: en

Keywords

ADULT BRAIN INJURY; BETA AMYLOID; EPIDEMIOLOGY; HEAD TRAUMA; PET SCANNING