Citation

Bouzat P, Ageron FX, Thomas M, Vallot C, Hautefeuille S, Schilte C, Payen JF. J. Neurotrauma 2019; ePub(ePub): ePub.

Affiliation

Hopital Albert Michallon, Anesthesiology and Critical care, Grenoble, France ; JFPayen@chu-grenoble.fr.

Copyright

(Copyright © 2019, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2019.6432

PMID

30990114

Abstract

After traumatic brain injury (TBI), the relationship between age and outcome at one-year, including quality of life, has been poorly explored. The aim of our study was to describe this relationship in a cohort of TBI patients in a regional trauma system. Consecutive TBI patients with severe lesions on initial brain CT scan were included from July 2014 to July 2016 in two French level-I trauma centers. The primary outcome was the mortality at one-year and secondary outcomes were Extended-Glasgow Outcome Scale (GOS-E) and quality of life using the Short Form health survey (SF-12). The relationship between age and outcome was modelled using generalized linear model (GLM). Within the study period, 427 patients with TBI and type-3 abbreviated injury score lesions were included. Finally, 380 patients were assessed for mortality. Ninety-six (25%) patients died at one year. The detailed neurologic status was available for 317 patients. One year after the trauma, 141 (44%) patients had favorable outcome (GOS-E 7 and 8) while 53 (17%) patients had moderate disability (GOS-E 5-6), 27 (9%) patients had severe disability or vegetative state (GOS-E 2-4) and 96 (30%) patients died (GOS-E 1). After 70-year-old, a dramatic increase in the odds of death and poor neurologic outcome was found using GLM. No difference according to age was found for the quality of life. After TBI, the mortality at one year dramatically increased with age after 70 years. For elderly survivors, impairment of quality of life was not different from younger patients.

Language: en

Keywords

OUTCOME MEASURES; REHABILITATION; TRAUMATIC BRAIN INJURY