CONTACT US: Contact info
|
Citation |
Sheerin CM, Kovalchick LV, Overstreet C, Rappaport LM, Williamson V, Vladimirov V, Ruggiero KJ, Amstadter AB. Brain Sci. 2019; 9(6): e9060146. |
|
Affiliation |
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA. Ananda.Amstadter@vcuhealth.org. |
|
Copyright |
(Copyright © 2019, Switzerland Molecular Diversity Preservation International (MDPI) AG) |
|
DOI |
|
PMID |
31226868 |
|
Abstract |
: Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are underrepresented in genetic studies. In an epidemiologic sample tornado-exposed adolescents (n = 707, 51% female, Mage = 14.54 years), trajectories of PTSD symptoms were examined at baseline and at 4-months and 12-months following baseline. This study aimed to determine if rare genetic variation in genes previously found in the sample to be related to PTSD diagnosis at baseline (MPHOSPH9, LGALS13, SLC2A2), environmental factors (disaster severity, social support), or their interplay were associated with symptom trajectories. A series of mixed effects models were conducted. Symptoms decreased over the three time points. Elevated tornado severity was associated with elevated baseline symptoms. Elevated recreational support was associated with lower baseline symptoms and attenuated improvement over time. Greater LGLAS13 variants attenuated symptom improvement over time. An interaction between MPHOSPH9 variants and tornado severity was associated with elevated baseline symptoms, but not change over time. Language: en |
|
Keywords |
G × E; PTSD; adolescent risk; longitudinal; natural disaster trauma; rare variants |