Citation

Le Sage N, Tardif PA, Frenette J, Emond M, Chauny JM, Moore L, Archambault P, Perry J, Boulanger-Piette A. Can. J. Neurol. Sci. 2019; ePub(ePub): 1-4.

Affiliation

Centre Hospitalier Universitaire de Québec-Centre de Recherche du Centre Hospitalier de l'Université Laval,Université Laval,Québec, QC,Canada.

Copyright

(Copyright © 2019, Canadian Journal of Neurological Sciences)

DOI

10.1017/cjn.2019.61

PMID

31317855

Abstract

This study assessed whether S-100β protein could be measured in urine when detectable in plasma after a mild traumatic brain injury (mTBI). Clinical data, plasma and urine samples were collected for the 46 adult patients prospectively enrolled in the emergency department (ED) of a Level 1 trauma center. S-100β protein concentrations were analysed using ELISA. S-100β protein was detectable in 91% and 71% of plasma and urine samples, but values were not correlated (r = 0.002). Urine sampling would have been a non-invasive procedure, but it does not appear to be useful in the ED during the acute phase after an mTBI.

Language: en

Keywords

Biomarkers; Brain injury - Traumatic; Head trauma; Neuroimaging; Trauma