Citation

Garcia Denegri ME, Bustillo S, Gay CC, Van De Velde A, Gomez G, Echeverría S, Gauna Pereira MDC, Maruñak S, Nuñez S, Bogado F, Sanchez M, Teibler GP, Fusco L, Leiva LCA. Curr. Top. Med. Chem. 2019; ePub(ePub): ePub.

Affiliation

Laboratorio de Investigación en Proteínas. Instituto de Química Básica y Aplicada del Nordeste Argentino (UNNE-CONICET). Facultad de Ciencias Exactas y Naturales y Agrimensura. Corrientes, Argentina. Laboratorio de Toxicología Veterinaria dependiente de la Cátedra de Farmacología y Veterinaria. Facultad de Ciencias Veterinarias. Universidad Nacional del Nordeste. Corrientes. Argentina.

Copyright

(Copyright © 2019, Bentham Science Publishers)

DOI

10.2174/1568026619666190725094851

PMID

31345151

Abstract

Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Language: en

Keywords

Bothrops alternatus; Bothrops diporus; Crotalus durisus terrificus; crotoxin; metalloproteinases; phospholipases A2; serine/thrombin-like proteinases; serinoproteases; snake venom