Citation

Jaiswal S, Knutsen AK, Wilson CM, Fu AH, Tucker LB, Kim Y, Bittner KC, Whiting MD, McCabe JT, Dardzinski BJ. Brain Res. 2019; ePub(ePub): ePub.

Affiliation

Translational Imaging Core, Center for Neuroscience and Regenerative Medicine (CNRM), Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, United States; Department of Radiology and Radiological Sciences, USUHS, MD, United States. Electronic address: bernard.dardzinski@usuhs.edu.

Copyright

(Copyright © 2019, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

10.1016/j.brainres.2019.146400

PMID

31445032

Abstract

Changes in ¹⁸F-fluorodeoxyglucose ([¹⁸F]FDG) measured by positron emission tomography (PET) can be used for the noninvasive detection of metabolic dysfunction following mild traumatic brain injury (mTBI). This study examined the time course of metabolic changes induced by primary blast injury by measuring regional [¹⁸F]FDG uptake. Adult, male rats were exposed to blast overpressure (15 psi) or sham injury, and [¹⁸F]FDG uptake was measured before injury and again at 1-3 h and 7 days post-injury, using both volume-of-interest (VOI) and voxel-based analysis. VOI analysis revealed significantly increased [¹⁸F]FDG uptake in corpus callosum and amygdala at both 1-3 h and 7 days following blast, while a transient decrease in uptake was observed in the midbrain at 1-3 h only. Voxel-based analysis revealed similar significant differences in uptake between sham and blast-injured rats at both time points. At 1-3 h post-injury, clusters of increased uptake were found in the amygdala, somatosensory cortex, and corpus callosum, while regions of decreased uptake were observed in midbrain structures (inferior colliculus, ventrolateral tegmental area) and dorsal auditory cortex. At day 7, a region of increased uptake in blast-injured rats was found in a cluster centered on the cortex-amygdala transition zone, while no regions of decreased uptake were observed. These results suggest that a relatively mild primary blast injury results in altered brain metabolism in multiple brain regions and that post-injury time of assessment is an important factor in observing regional changes in [¹⁸F]FDG uptake.

Copyright © 2019. Published by Elsevier B.V.

Language: en

Keywords

blast; fluorodeoxyglucose; mild traumatic brain injury; positron emission tomography