CONTACT US: Contact info
|
Citation |
Villa J, Ehret BC, Depp CA. Crisis 2019; ePub(ePub): ePub. |
|
Affiliation |
Department of Psychiatry, Stein Institute for Research on Aging, University of California San Diego, La Jolla, CA, USA. |
|
Copyright |
(Copyright © 2019, International Association for Suicide Prevention, Publisher Hogrefe Publishing) |
|
DOI |
|
PMID |
31657642 |
|
Abstract |
Background: Psychosis is a significant, yet understudied, risk factor for suicide. There has yet to be a systematic investigation examining the rate and predictors of inclusion of psychotic disorders or symptoms in suicide-focused trials. Aim: Our aim was to conduct a systematic review of inclusion/exclusion of psychosis in studies with suicidal ideation or behavior as a primary endpoint, rate of inclusion across intervention type and other characteristics, and criteria used to exclude psychosis and accompanying rationale. Method: A literature search was conducted using PubMed, Cochrane Library, and PsycInfo to identify relevant articles published between 2000 and 2018. Statements regarding inclusion/exclusion were codified by authors. Results: Out of 122 studies selected, 75 (61.5%) excluded individuals with psychosis. This rate varied by intervention and sample size, but not by year of study or country of origin. Only 9% provided a rationale for psychosis exclusion. Limitations: Minimal reporting of participants' diagnosis in studies disallowed analysis of the rate of inclusion of psychosis in samples. Conclusion: Three out of five trials with suicide-related primary outcomes excluded psychosis; thus, people with psychosis are poorly represented in suicide-specific studies. This disparity could be remedied by either adapting protocols to include people with psychosis or developing new, tailored treatments. Language: en |
|
Keywords |
clinical trial; intervention; psychosis; suicide |