Citation

Bocarsly ME, da Silva E Silva D, Kolb V, Luderman KD, Shashikiran S, Rubinstein M, Sibley DR, Dobbs LK, Alvarez VA. Cell Rep. 2019; 29(5): 1147-1163.

Affiliation

Laboratory on the Neurobiology of Compulsive Behaviors, NIAAA, NIH, Bethesda, MD, USA; Center on Compulsive Behaviors, IRP, NIH, Bethesda, MD, USA; NIDA, IRP, NIH, Bethesda, MD, USA. Electronic address: veronica.alvarez@nih.gov.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.celrep.2019.09.059

PMID

31665630

Abstract

Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate a causal link with another liability factor: low expression of striatal dopamine D2 receptors (D2Rs). Using transgenic mouse lines, we find that the selective loss of D2Rs on striatal medium spiny neurons enhances sensitivity to ethanol stimulation and generates resilience to ethanol sedation. These mice also display higher preference and escalation of ethanol drinking, which continues despite adverse outcomes. We find that striatal D1R activation is required for ethanol stimulation and that this signaling is enhanced in mice with low striatal D2Rs. These data demonstrate a link between two vulnerability factors for alcohol abuse and offer evidence for a mechanism in which low striatal D2Rs trigger D1R hypersensitivity, ultimately leading to compulsive-like drinking.

Published by Elsevier Inc.

Language: en

Keywords

alcohol use disorders; dopamine D1 receptors; dorsal medial striatum; ethanol; ethanol self-administration; loss of righting reflex; sedation; striatum