Citation

Sun Y, Bai L, Niu X, Wang Z, Yin B, Bai G, Zhang D, Gan S, Sun C, Wang S, Zhu F, Zhang M. Front. Neurol. 2019; 10: e1120.

Affiliation

Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Copyright

(Copyright © 2019, Frontiers Research Foundation)

DOI

10.3389/fneur.2019.01120

PMID

31708858

PMCID

PMC6819507

Abstract

Mild traumatic brain injury (mTBI) is the most common neurological insult and leads to long-lasting cognitive impairments. The immune system modulates brain functions and plays a key role in cognitive deficits, however, the relationship between TBI-induced changes in inflammation-related cytokine levels and cognitive consequences is unclear. This was investigated in the present study in two cohorts of individuals within 1 week of mTBI (n = 52, n = 43) and 54 matched healthy control subjects. Patients with mTBI were also followed up at 1 and 3 months post-injury. Measures included cognitive assessments and a 9-plex panel of serum cytokines including interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12, chemokine ligand 2 (CCL2), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α). The contribution of cytokine levels to cognitive function was evaluated by multivariate linear regression analysis. The results showed that serum levels of IL-1β, IL-6, and CCL2 were acutely elevated in mTBI patients relative to controls; CCL2 level was remained high over 3 months whereas IL-1β and IL-6 levels were declined by 3 months post-injury. A high level of CCL2 was associated with greater severity of post-concussion symptoms (which survived in the multiple testing correction); elevated IL-1β was associated with worse working memory in acute phase (which failed in correction); and acute high CCL2 level predicted higher information processing speed at 3 months post-injury (which failed in correction). Thus, acute serum cytokine levels are useful for evaluating post-concussion symptoms and predicting cognitive outcome in participants with mTBI.

Copyright © 2019 Sun, Bai, Niu, Wang, Yin, Bai, Zhang, Gan, Sun, Wang, Zhu and Zhang.

Language: en

Keywords

cognitive performance; follow-up; inflammation-related cytokines; mild traumatic brain injury; post-concussion symptoms