Citation

Borçoi AR, Mendes SO, Gasparini Dos Santos J, Mota de Oliveira M, Moreno IAA, Freitas FV, Pinheiro JA, Arpini JK, Cunha ER, Archanjo AB, Evangelista Monteiro de Assis AL, Sorroche BP, Rebolho Batista Arantes LM, Borloti E, Álvares-da-Silva AM. J. Psychiatr. Res. 2019; 121: 24-30.

Affiliation

Programa de Pós Graduação em Biotecnologia /Renorbio, Universidade Federal do Espírito Santo, Vitória, ES, Brazil; Departmento de Biologia, Universidade Federal do Espírito Santo, Alegre, ES, Brazil.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.jpsychires.2019.10.011

PMID

31731185

Abstract

OBJECTIVE: The aim of this study was to verify determinant factors for depression and analyze the relationship between possible changes in HPA axis and depression, in this case NR3C1 DNA methylation and serum cortisol levels.

METHODS: 349 adult volunteers were recruited to evaluate depression, socio-demographic, economic and lifestyle factors, serum cortisol levels and NR3C1 DNA methylation by pyrosequencing. Depression determinant factors were investigated using a Poisson regression model with robust variance (p < 0.05).

RESULTS: Poisson regression with robust variance adjusted by gender, tobacco use, self-perceived stress, leisure activity, suicidal ideation, low cortisol levels and NR3C1 DNA methylation was performed and predicted risk factors for depression. Furthermore, depressive volunteers showed a significant increase in NR3C1 DNA methylation when compared to healthy volunteers.

CONCLUSIONS: This findings provide a basis for understanding the role of HPA axis in depression, especially its regulation by NR3C1 DNA methylation. Furthermore, it emphasizes the stressful lifestyle risk factors (female, tobacco uso, self perceived stress, leisure activities absence and suicidal ideation) that can contribute to future research and the search for public health policies to improve quality of live, mental and general health.

Copyright © 2019 Elsevier Ltd. All rights reserved.

Language: en