Citation

Wang H, Wang Y, Shi FF, Zhang S, Fang WT, Qi LM, Wang N, Huang C, Fang HQ, Li HJ. Toxicon 2019; ePub(ePub): ePub.

Affiliation

National Institute of Occupational Health and Poison Control, Chinese Centre for Disease Control and Prevention, Beijing 100050, China. Electronic address: lihaijiao715@126.com.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.toxicon.2019.11.007

PMID

31759921

Abstract

Amanita neoovoidea (genus Amanita Pers.) poisoning leads to acute renal failure. Here, we present seven case reports of acute renal failure with acute hepatic failure due to ingestion of A. neoovoidea. Clinical manifestations included gastrointestinal symptoms 1-72 h after ingestion; elevation of renal parameters and blood uric acid, blood urea nitrogen, and creatinine levels; a few abnormal hepatic parameters, primarily albumin decrease and alanine aminotransferase increase; and elevation of zymogram parameters such as cholinesterase and lactate dehydrogenase. To determine whether the hepatic/renal lesions were caused by amanitins, we analyzed the blood and urine samples of patients and specimens of poisonous mushrooms. Morphological and molecular biological analyses indicated that the mushroom was A. neoovoidea. However, no amatoxins and phallotoxins were detected in its basidiomata.

Copyright © 2019. Published by Elsevier Ltd.

Language: en

Keywords

Acute renal failure; Amanita neoovoidea; Poisonous mushroom; Treatment