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Citation |
Morin RT, Insel P, Bickford D, Nelson C, Mackin RS. Clin. Gerontol. 2019; ePub(ePub): ePub. |
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Affiliation |
MentalHealth Service, San Francisco VA Medical Center, San Francisco, California, USA. |
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Copyright |
(Copyright © 2019, Informa - Taylor and Francis Group) |
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DOI |
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PMID |
31865868 |
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Abstract |
Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD).Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression severity was measured using the 17-item Hamilton Depression Rating Scale (HDRS; cutoff ≥15). Frailty was assessed using several motor tests. The World Health Organization Disability Assessment Schedule (WHO-DAS) measured disability status. A linear regression analysis was performed to identify relationships of cognition, frailty and depression severity with disability.Results: The average number of impaired cognitive tests was 2.0 (SD = 1.9), with 28.2% of participants showing no impaired scores. On average participants reported depression severity of 17.3 (SD = 3.6), and disability total score of 15.1 (SD = 6.9). The regression model accounted for 25.1% of the variance in disability, with only depression severity significantly predicting disability status. Burden of cognitive impairment and frailty were not predictive of disability in this sample.Conclusions: In this sample, only depression severity was associated with increased disability.Clinical Implications: These findings have implications for intervention in LLD, as depression severity may represent a more modifiable risk factor for disability. Language: en |
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Keywords |
Late life depression; cognitive impairment; disability; frailty |