Citation

Sörbo A, Eiving I, Theodorsson E, Rydenhag B, Jonsdottir IH. Acta Neurol. Scand. 2019; ePub(ePub): ePub.

Affiliation

Institute of Stress Medicine, Region Västra Götaland, Gothenburg, Sweden.

Copyright

(Copyright © 2019, John Wiley and Sons)

DOI

10.1111/ane.13212

PMID

31879940

Abstract

OBJECTIVE: Satisfactory anabolic reactions, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, are essential following severe traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH). Many factors may influence this activation. This study aimed to investigate whether individuals who reported chronic diseases, psychosocial afflictions or stressful events before a severe brain injury display a different pattern regarding cortisol levels retrospectively and up to three months compared with those who did not report stressful experiences. MATERIALS & METHODS: Fifty-five patients aged 16-68 years who were admitted to the neurointensive care unit (NICU) were included. Hair cortisol measurements offer a unique opportunity to monitor cortisol levels retrospectively and after the trauma. Hair strands were collected as soon as possible after admission to the NICU and every month until three months after the injury/insult. The participants/relatives were asked about stressful events, psychosocial afflictions and recent and chronic diseases.

RESULTS: The group who reported chronic diseases and/or stressful events before the brain injury had more than twice as high median hair cortisol levels before the brain injury compared with those who did not report stress, but the difference was not statistically significant (p=0.12). Those who reported stress before the brain injury had statistically significantly lower hair cortisol values after the brain injury and they remained until three months after the injury.

CONCLUSIONS: Stressful events and/or chronic disease before brain injury might affect mobilization of adequate stress reactions following the trauma. However, the large variability in cortisol levels in these patients does not allow firm conclusions and more studies are needed.

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Language: en

Keywords

Severe brain injury; hair cortisol; pre-traumatic conditions; stress