Citation

Janiri D, Kotzalidis GD, De Chiara L, Koukopoulos AE, Aas M, Sani G. Psychiatr. Clin. North Am. 2020; 43(1): 69-82.

Affiliation

Institute of Psychiatry, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Psychiatry, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.psc.2019.10.007

PMID

32008689

Abstract

Childhood trauma (CT) is strongly associated with bipolar disorder, possibly through emotional hyperreactivity (EH). Mixed symptoms/states (MSs) are associated with increased illness severity. The authors tested through a systematic review the association between CT and MSs. The authors systematically looked for studies exploring associations between MSs and CT, CT and EH, and EH and MSs. Most literature agrees that MSs are associated with CT; the latter was found to be associated to EH, which is in turn associated with MSs. The literature supports an association between CT and later development of MSs, possibly mediated through EH.

Copyright © 2019 Elsevier Inc. All rights reserved.

Language: en

Keywords

Affective lability; Bipolar disorders; Childhood trauma; Depression; Emotional reactivity; Emotional regulation; Mixed states; Mood disorders