Citation

Lira JLO, Ugrinowitsch C, Coelho DB, Teixeira LA, de Lima-Pardini AC, Magalhães FH, Barbosa ER, Horak FB, Silva-Batista C. J. Physiol. 2020; ePub(ePub): ePub.

Affiliation

Exercise Neuroscience Research Group, School of Arts, Sciences and Humanities, University of São Paulo, SP, Brazil.

Copyright

(Copyright © 2020, The Physiological Society, Publisher John Wiley and Sons)

DOI

10.1113/JP279068

PMID

32020612

Abstract

KEY POINTS: Individuals with freezing of gait (FoG) due to Parkinson's disease (PD) have small and long anticipatory postural adjustments (APA) associated with delayed step initiation. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs due to supraspinal dysfunction. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, it may be deficient in freezers during APAs. We show that freezers presented PSI in quiet stance (control task), but they presented loss of PSI (i.e. higher ratio of the conditioned H-reflex relative to the test H-reflex) during APAs prior to step initiation (functional task), whereas non-freezers and healthy control individuals presented PSI in both the tasks. The loss of PSI in freezers was associated with both small APA amplitudes and FoG severity. We hypothesize that loss of PSI during APA for step initiation in freezers may be due to FoG. ABSTRACT: Freezing of gait (FoG) in Parkinson's disease involves deficient anticipatory postural adjustments (APAs) resulting in cessation of step initiation due to supraspinal dysfunction. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, here we hypothesized a loss of PSI in freezers during APA for step initiation, which would be associated with FoG severity. Seventy individuals (27 freezers, 22 non-freezers, and 21 age-matched healthy controls [HC]) performed a GO-commanded step initiation task on a force platform under 3 conditions: 1) without electrical stimulation; 2) test Hoffman reflex (H-reflex); and 3) conditioned H-reflex. They also performed a control task (quiet stance). In the step initiation task, the H-reflexes were evoked on the soleus muscle when the amplitude of the APA exceeded 10-20% of the mean of the baseline mediolateral force. PSI was quantified by the ratio of the conditioned H-reflex relative to the test H-reflex in both the tasks.

OBJECTIVE assessment of FoG severity (FoG-ratio) was performed. Freezers presented lower PSI levels during quiet stance than non-freezers and HC (P<0.05). During step initiation, freezers presented loss of PSI and lower APA amplitudes than non-freezers and HC (P<0.05). Significant correlations were only found for freezers between loss of PSI and FoG-ratio (r = 0.59, P = 0.0005) and loss of PSI and APA amplitude (r = -0.35, P < 0.036). Our findings suggest that loss of PSI for step initiation in freezers may be due to FoG. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Language: en

Keywords

H-reflex; freezers; inhibition; sensorimotor integration; spinal inhibitory mechanism; step initiation