Citation

Pohanka M. Mini Rev. Med. Chem. 2020; ePub(ePub): ePub.

Affiliation

Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove CZ-50001. Czech Republic.

Copyright

(Copyright © 2020, Bentham Science Publishers)

DOI

10.2174/1389557520666200228105312

PMID

32108007

Abstract

Botulinum toxin is a neurotoxin produced by Clostridium botulinum and some other relative species. It causes lethal disease called botulism. It can enter body via infections by Clostridium (e.g. wound and children botulism) or by a direct contact with the toxin or eating a contaminated food (food-borne botulism). Botulinum toxin is also considered as a relevant biological warfare agent with expected high number of causalities when misused for bioterrorist or military purposes. The current paper surveys the actual knowledge about botulinum toxin pathogenesis, manifestation of poisoning, current trends in diagnostic and therapy. Relevant and recent literature is summarized in this paper.

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Language: en

Keywords

Acetylcholine; Antiserum; Biological Warfare Agent; Botulinum toxin; Botulism; Clostridium botulinum; Detection; Diagnosis; Poisoning